Global properties of an age-structured virus model with saturated antibody immune response, multi-target cells and general incidence rate

Some viruses, such as human immunodeficiency virus, can infect several types of cell populations. The age of infection can also affect the dynamics of infected cells and production of viral particles. In this work, we study a virus model with infection-age and different types of target cells which takes into account the saturation effect in antibody immune response and a general non-linear infection rate. We construct suitable Lyapunov functionals to show that the global dynamics of the model is completely determined by two critical values: the basic reproduction number of virus and the reproductive number of antibody response

Microarrays as a functional approach to the transcriptome

Knowing a cell’s transcriptome is a fundamental requisite in order to analyze its response to the environment. Microarrays have supposed a revolution on this field as they are able to yield an overview of gene expression at any environmental condition on a genome-wide scale. This technique consists in the hybridisation of a nucleic acid sample, previously marked, with a probe (which might be made up of cDNA, oligonucleotides or PCR products) anchored to a solid surface (made of glass, plastic, silicon...) giving as a result a dot grid which reveals, after image analysis, which genes are being expressed. Nevertheless, this only can be achieved if information on the species genome has been generated. Different kinds of expression microarrays exist attending to the probe’s nature and the method used in its synthesis. In this poster two of these will be treated: Spotted Microarrays, for which the probe is synthesised prior to its fixation to the array and allow the analysis of two targets simultaneously. They can be easily customized, but lack high reproducibility and sensitivity. Oligonucleotide Microarrays, which are characterized by the direct printing of the probe on the array. In this case the probes consist on, invariably, oligonucleotides that are complementary to a small fraction of the gene it is representing at the microarray. Their application is somewhat restricted. This fact, however, makes them more reproducible. Currently, the approach towards the transcriptome studies from the Next Generation Sequencing technologies offers a large volume of information in a short amount of time needing less previous information on the target organism than that needed by microarrays, but their expensive price limits their use. The versatility of the latter, together with their reduced costs in comparison to other techniques, makes them an interesting resource in applications that may need less complexity

Light transmission in nanocellular polymers: Are semi-transparent cellular polymers possible?

This work presents the light transmission through a collection of solid cellular polymers based on poly (methyl methacrylate) (PMMA) with cells sizes covering the micro and nano-scale. The obtained results showed that the behavior of light transmission when cell size is in the nano-scale is opposite to the one shown by microcellular foams or the one predicted by theoretical models of light scattering (LS). In fact, the expected trend is that a reduction of cell size increases the opacity of the samples. However, for nanocellular polymers based on amorphous polymers reducing the cell size increases the light transmission. Therefore, this result indicates that a further reduction of the cell size could result in cellular polymers optically semi-transparen

Performance analysis of joint precoding and MUD techniques in multibeam satellite systems

This paper considers interference mitigation techniques in the forward link of multibeam satellite systems. In contrast to previous works, either devoted to receiver interference mitigation (e.g. multiuser detection) or transmitter interference mitigation (precoding), this work evaluates the achievable rates of the joint combination of both techniques. On the one hand, precoding cannot properly mitigate all the inter- beam interference while maintaining a sufficiently high signal-to-noise ratio. On the other hand, the receiver cost and complexity exponentially increases with the number of signals to be simultaneously detected. This highlights that the receiver cannot deal with all the interferences so that in general only 2 signals are jointly detected. As a result, the use of precoding within a coverage area jointly with multiuser detection can both benefit from each other and extremely increase the achievable rates of the system. This is numerically evaluated in a close-to-real coverage area considering simultaneous non-unique decoding strategies. The results show the benefits of this joint scheme that eventually can increase the current precoding performance a 23%.Peer ReviewedPostprint (author's final draft

NOMA and interference limited satellite scenarios

This paper deals with the problem of non-orthogonal multiple access (NOMA) in multibeam satellite systems, where the signals are jointly precoded. It is considered that the number of frames that are simultaneously transmitted is higher than the number of feeds, reducing the precoding interference mitigation capabilities as the system becomes overloaded. In order to solve this problem, we assume that the satellite user terminals are able to perform multi-user detection to mitigate the interference. In the current NOMA approach, it is assumed a successive interference cancellation (SIC) receiver. To increase the spectral efficiency, this paper investigates NOMA with simultaneous non-unique detection (SND). Compared to the case where user terminals perform single user detection (SUD), conventional scheduling heuristic rules do not longer apply in this scenario. Therefore, different scheduling algorithms are proposed considering both SIC and SND strategies. As the numerical evaluations show, SND yields larger average data rates than the SIC receiver. Concerning the scheduling, the best strategy is to pair users with highly correlated channels and the lowest channel gain difference. It is also shown that the sum-rate can be increased in overloaded satellite systems with respect to satellite scenarios, where the number of transmitted frames and feeds is the same.Peer ReviewedPostprint (author's final draft